As COVID-19 continues to be a global threat to health and society, WHO and the Technical Advisory Group (TAG) on Immunization and Vaccine-Preventable Diseases in the Western Pacific Region recommended updating the Western Pacific Regional Road Map for COVID-19 Vaccination Response 2021–2022 during the 31st TAG meeting in June 2022. The updated Road Map will provide future directions to countries and areas considering the achievements, challenges and opportunities the COVID-19 vaccination response has provided and laid out.