TechNet-21 - Forum

This forum provides a place for members to ask questions, share experiences, coordinate activities, and discuss recent developments in immunization.

Discussions tagged CTC

Launched today: Special Edition of Vaccine “Building Next Generation Immunization Supply Chains"

PATH is pleased to present “Building Next Generation Immunization Supply Chains” a special edition of Vaccine journal which brings together evidence from global experts in 31 articles representing decades of work by country governments, implementing partners, and donors to improve immunization supply chains (iSC). The articles address the impact of iSC on vaccine coverage, current challenges, and successful pilots, prom...

IPAC position statement on the Controlled Temperature Chain (CTC) and the use of vaccines Out of Cold Chain (OCC)

Dear all,

I would like to share with you a position statement from the Immunization Practices Advisory Committee (IPAC) on the Controlled Temperature Chain (CTC) and the use of vaccines out of cold chain (OCC). This statement has been prepared by the CTC working group, which has been established under the authority of IPAC in July 2016.The mission of this working group is to convene key stakeholders to define a shared vision and strategy for CTC. Members of the group include subject m...

A Supply Chain for outreach immunization?

Immunization outreach services depend on a protective, affordable and efficient supply chain to benefit rather than obstruct outreach operations. Four potential cold-chain solutions are on offer but each has barriers to be negotiated or removed. The options are:

Frozen water packs BUT we should switch to freeze-free vaccine carriers to avoid the risk of freezing: Vaccines certified for use in a ‘Controlled Temperature Chain’: PCM-filled packs used in all existing carriers and boxes p...

ECTC, CTC & VVM

Hi all,

I am quite new to the CTC adventure.

After reading the second draft of the WHO CTC guideline, now ECTC (I also wen through the first version and the discussion in Langen and Ottawa), several questions came to my mind, and I would be extremely grateful if some of the forum members can help me out with them

1- Now that the rigid time& temperature conditions of the CTC are only one of the extended temperature conditions eligible for re-labelling, can we assume tha...

New! 3-part film on the Controlled Temperature Chain (CTC)

I’m delighted to announce the online release of WHO’s new 3-part film on the Controlled Temperature Chain (CTC) produced by IVB/EPI in both English and French.

This 3-episode film on CTC serves as an advocacy tool in order to promote the approach among varied stakeholders. The first episode explains what CTC is, why it is useful and how it is feasible. The second episode f...

Buffered Temperature Chain

How about a Buffered Temperature Chain (BTC)? Vaccines which are highly thermally stable can be distributed in the Controlled Temperature Chain (CTC). To be incorporated into the CTC the vaccines must be stable enough to be stored for 3 days at 40 deg C. There are very few vaccines which are this stable. If vaccines can be incorporated into the CTC there are numerous logistical and financial advantages. Since the infrastructure is much simpler and less expensive. Establishing a “Buffered Temp...

New CTC infographic available

A new infographic that explains "What is a controlled temperature chain (CTC)?" is available on the WHO website:

http://www.who.int/immunization/programmes_systems/supply_chain/resources/WHO_CTC_Infographic.pdf

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Everything you wanted to know about CTC but were afraid to ask…

In recognition that an increasing number of vaccines are able to tolerate temperatures well above those officially stated on their labels, the World Health Organization (WHO) has been supporting efforts to assess and take advantage of the true heat stability of vaccines. Upstream work in this regard includes dialogue with vaccine manufacturers to ensure that new vaccines, where possible, reflect a maximum heat stability compatible with WHO’s definition of a Controlled Temperature Chain (CTC) a...

CTC used in Mauritania

Last week marked the second occasion that a Controlled Temperature Chain (CTC) has been officially used with a vaccine licensed, pre-qualified, and labelled accordingly. Mauritania has just completed a Meningitis A immunization campaign (scheduled from October 14th to the 23rd) using the Meningococcal A conjugate vaccine, MenAfrivac. Two districts with particularly pronounced cold chain constraints were selected as appropriate candidates for a CTC approach: Rosso and Maghta Lahjar. Following...

Immunogenicity and safety of tetanus toxoid vaccine in Controlled Temperature Chain

The results of a study conducted by Epicentre /Médecins Sans Frontières (MSF) assessing the immunogenicity and safety of a tetanus toxoid vaccine have been recently published in Vaccine.[sup]1 [/sup] The study was conducted in collaboration with the Project Optimize, the Belgian Institute of Public Health (WIV-ISP) and the Ministry of Health of Chad. A cluster randomized, non-inferiority trial was conducted in Moïssala district, Chad, between December 2012 and March 2013. Prior to the study, st...

Call for less heat-sensitive vaccines

A couple of months ago, Médecins Sans Frontières (MSF) produced a package of materials in support of their call for wider use of existing vaccines in the “controlled temperature chain” or CTC. An issue brief, Vaccinating Children Beyond the Cold Chain, is available in English and French. It is attached to this message. The Issue Brief, as well as animation and infographics on CTC and the thermostability of vaccines, are available from

World Immunization Week: MSF calling for heat-stable vaccines to help reach the one in five children

This note has been cross-posted from the GAVI CSO forum with many thanks! Dear colleagues, This week on occasion of the World Immunization Week, Médecins Sans Frontières/Doctors Without Borders (MSF) has released a call for greater attention to the need for heat-stable vaccines to facilitate access to life saving vaccinations to the one in five children currently left out of global immunization efforts. You can find more information on the call for heat-stable vaccines below, including...

Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns

The need to keep vaccines in a 2°C to 8°C cold chain is a constraining factor for many immunization campaigns due to limited storage capacity and/or limited ice pack freezing capacity; supplementary immunization activities planned across sub-Saharan Africa to introduce MenAfriVac™ are a good example. In 2012, the licence for the Serum Institute of India’s meningitis A vaccine, MenAfriVac®, was changed based on a thorough review of scientific data by regulatory authorities and the World Health Or...

In Pictures: Delivering MenAfriVac using the CTC approach

by Dan Brigden, PATH In November 2012, the first immunization campaign to use a controlled temperature chain (CTC) took place in Banikoara in northern Benin. This photo set contains photographs taken during the campaign, where over 155,000 people were vaccinated using the CTC approach.

Notes from the field: Delivering MenAfriVac using the CTC approach

by Simona Zipursky, PATH; Mamoudou Harouna Djingarey, WHO/AFRO; Olivier Ronveaux, WHO/AFRO; Sylvestre Tiendrebeogo, Consultant In November 2012, the first immunization campaign to use a controlled temperature chain (CTC) took place in Banikoara in northern Benin. MenAfriVac is a meningitis A vaccine developed by the Serum Institute of India with support from PATH and the World Health Organization (WHO) through the

Stable vaccines at tropical temperatures

http://www.timesche nnai.com/ index.php? mod=article&cat=General&article=47839 Now vaccines can be stored at room temperature 02.18.2010 (GMT+5.5) London: For the first time scientists at Oxford University have found a way of keeping vaccines stable without refrigeration, even at tropical temperatures.The technology has the potential to revolutionise vaccination efforts,...

Increasing the acceptable temperature range for certain vaccines

by Michel Zaffran, WHO; Julie Milstien, consultant; and Modibo Dicko, WHO It has long been known that certain vaccines are stable for long periods of time at temperatures outside the standard cold chain protocol of 2[sup]o[/sup] to 8[sup]o[/sup]C. However, until recently, there have been few reasons to consider changing the relatively simple, blanket policy that all...

What's in a name? Selecting a term for 'storing and transporting vaccines outside of the 2-8°C range'

Today, most vaccines are licensed for storage between 2-8°C, regardless of their true stability. While there are some vaccines that do need to be kept at this specific temperature range, studies have shown that most vaccines are able to withstand higher temperature ranges for a specific period of time and that keeping them at 2-8°C puts some of them at risk of freeze damage. This isn't to say that vaccines should not still be stored at 2-8°C, but that if the vaccine is in fact stable enough to a...

Oral Polio Delivered Safely Without Icepacks in Recent Study

Oral Polio Delivered Safely Without Icepacks in Recent Study by Ariane Halm, EPIET (European Programme for Intervention Epidemiology Training), and Olivier Ronveaux, WHO Optimizerecently completed a study with the World Health Organization (WHO) Country Office and the Ministry of Health in Mali to determine the feasibility of usin...

POST 00724E : COOL TECHNOLOGY : THE END OF THE COLD-CHAIN?

POST 00724E : COOL TECHNOLOGY : THE END OF THE COLD-CHAIN? 8 November 2004 _____________________________________ Below is an article published in "The Economist". The delay in posting it was due to the translating into French. Do not dwell on the few simplifications or generalizations of a journalistic nature. It is the essence that counts! This article has also been added in both languages to the "General News" sub-page of our site at :
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