Journal article

Hepatitis B vaccine in healthy hospital employees

A low rate of seroconversion to hepatitis B vaccine is reported. This occurred in healthy hospital employees from two separate institutions. A total of 236 individuals were evaluated in this study and only 53% or 124 persons developed protective levels of antibody to hepatitis B surface antigen following a complete vaccine series. In one hospital, 30% of the vaccine recipients developed antibody but not to a protective level. Employees who received the entire series in the arm or in the arm and buttock (mixed) had a significantly greater number of responders than employees who received the entire series in the buttock (P less than .05). Recipients aged 50 to 59 years had a significantly lower response rate to the vaccine (P less than .05). There was no correlation with the vaccinee\'s sex or the timing of the second injection. Vaccine was noted to have frozen in one hospital and accounted for some loss of antigenicity. This failure to respond to the vaccine has necessitated the use of booster injections of vaccine and continued antibody monitoring.

Languages

  • English

Journal

Infection Control

Volume

7

Type

Journal article

Categories

  • Vaccines & delivery devices

Topic references

FREEZE-PREVENTION-POTENCY

TitleAuthorYearTypeLanguage
Assessing the potency and immunogenicity of inactivated poliovirus vaccine after exposure to freezing temperaturesAbhijeet Anand, Cynthia J. Snider, Dexiang Chen, Diana Kouiavskaia, Edmond F. Maes, Eric Stevens, Howard E. Gary Jr., Jacqueline Fournier-Caruana, Jessica A. White, Konstantin Chumakov, M. Steven Oberste, Marcus Estrada, William C. WeldonJournal articleEnglish
Cold chain study: danger of freezing vaccinesP. MilhommeJournal articleEnglish
Comparison of hepatitis B vaccine coverage and effectiveness among urban and rural Mongolian 2-year-oldsAnn Marie Kimball, Arslan Rinchin, J. Khulan, James S. Edstam, Nyamkhuu Dulmaa, Pagbajabyn NymadawaJournal articleEnglish
Effects of freezing on DPT and DPT-IPV vaccines, adsorbedA. Bell, D. Scheifele, R. DimayugaJournal articleEnglish, French
Factors affecting the immunogenicity and potency of tetanus toxoid: implications for the elimination of neonatal and non-neonatal tetanus as public health problemsA. Galazka, F. van Loon, S. Cochi, V. DietzJournal articleEnglish
Hepatitis B vaccineArlene A. McLean, Raymond Shaw Jr.Journal articleEnglish
Hepatitis B vaccine in healthy hospital employeesR. Normand, R. Silberman, S. A. KlotzJournal articleEnglish
Performance and potency of tetanus toxoid: implications for eliminating neonatal tetanusF. van Loon, J. B. Milstien, J. Bennett, S. Cochi, V. DietzJournal articleEnglish
Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particlesDvorah Diminsky, Marian Gorecki, Neomi Moav, Yechezkel BarenholzJournal articleEnglish
Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccinesChristina Ann Boros, D. M. Roberton, M. Hanlon, Michael Steven GoldJournal articleEnglish

Added by: Joseph Little

Added on: 2023-07-04 03:40:43

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