Journal article
Hepatitis B vaccine in healthy hospital employees
A low rate of seroconversion to hepatitis B vaccine is reported. This occurred in healthy hospital employees from two separate institutions. A total of 236 individuals were evaluated in this study and only 53% or 124 persons developed protective levels of antibody to hepatitis B surface antigen following a complete vaccine series. In one hospital, 30% of the vaccine recipients developed antibody but not to a protective level. Employees who received the entire series in the arm or in the arm and buttock (mixed) had a significantly greater number of responders than employees who received the entire series in the buttock (P less than .05). Recipients aged 50 to 59 years had a significantly lower response rate to the vaccine (P less than .05). There was no correlation with the vaccinee\'s sex or the timing of the second injection. Vaccine was noted to have frozen in one hospital and accounted for some loss of antigenicity. This failure to respond to the vaccine has necessitated the use of booster injections of vaccine and continued antibody monitoring.
Authors
Languages
- English
Journal
Infection Control
Volume
7
Type
Journal article
Categories
- Vaccines & delivery devices
Topic references
FREEZE-PREVENTION-POTENCY
Title | Author | Year | Type | Language |
---|---|---|---|---|
Assessing the potency and immunogenicity of inactivated poliovirus vaccine after exposure to freezing temperatures | Abhijeet Anand, Cynthia J. Snider, Dexiang Chen, Diana Kouiavskaia, Edmond F. Maes, Eric Stevens, Howard E. Gary Jr., Jacqueline Fournier-Caruana, Jessica A. White, Konstantin Chumakov, M. Steven Oberste, Marcus Estrada, William C. Weldon | Journal article | English | |
Cold chain study: danger of freezing vaccines | P. Milhomme | Journal article | English | |
Comparison of hepatitis B vaccine coverage and effectiveness among urban and rural Mongolian 2-year-olds | Ann Marie Kimball, Arslan Rinchin, J. Khulan, James S. Edstam, Nyamkhuu Dulmaa, Pagbajabyn Nymadawa | Journal article | English | |
Effects of freezing on DPT and DPT-IPV vaccines, adsorbed | A. Bell, D. Scheifele, R. Dimayuga | Journal article | English, French | |
Factors affecting the immunogenicity and potency of tetanus toxoid: implications for the elimination of neonatal and non-neonatal tetanus as public health problems | A. Galazka, F. van Loon, S. Cochi, V. Dietz | Journal article | English | |
Hepatitis B vaccine | Arlene A. McLean, Raymond Shaw Jr. | Journal article | English | |
Hepatitis B vaccine in healthy hospital employees | R. Normand, R. Silberman, S. A. Klotz | Journal article | English | |
Performance and potency of tetanus toxoid: implications for eliminating neonatal tetanus | F. van Loon, J. B. Milstien, J. Bennett, S. Cochi, V. Dietz | Journal article | English | |
Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles | Dvorah Diminsky, Marian Gorecki, Neomi Moav, Yechezkel Barenholz | Journal article | English | |
Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines | Christina Ann Boros, D. M. Roberton, M. Hanlon, Michael Steven Gold | Journal article | English |