In this webinar, our speaker shared lessons learned from the process of developing and implementing the Expanded Program on Immunization (EPI) Data Management System in Cameroon. The presentation explains the tools that were applied, the actors at play, and the approach taken. Our speaker discussed the challenges encountered during the process and changes made to overcome them by highlighting critical areas of prioritization. This webinar should be of interest to health information systems and data management specialists as well as healthcare practitioners committed to improving health information systems in the African context.