High-quality data are essential for immunization programs. As a data-intensive public health service, immunization is an apt case study for the generation, quality, and use of data to inform decision-making and guide programmatic improvements to reach all populations. In Ethiopia, JSI’s RED-QI approach sought to strengthen data use by incorporating use of different types of data collated from a variety of sources. This brief, written by JSI in 2021, provides recommendations for improving data use to achieve more equitable service delivery in Ethiopia.