This guidance is focused on establishing and managing a UCC system. It provides practical guidance to support countries in planning and selecting the appropriate UCC system design and equipment based on their local context. It outlines the considerations to ensure the UCC equipment will remain functional and utilized even after the Pfizer-BioNTech COVID-19 Vaccine supply has been fully utilized. The implementation considerations apply to countries that are planning to establish a UCC system and to those that already received/installed the UCC equipment.