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The costing tool enables the user to estimate the value of incremental (additional) resources required to add oral cholera vaccination campaigns to an existing immunization programme. The CholTool is...
Global Task Force on Cholera Control
Ending Cholera—A Global Roadmap to 2030 operationalises the new global strategy for cholera control at the country level and provides a concrete path toward a world in which cholera is no longer a...
World Health Organization (WHO)
The Series “The Immunological Basis for immunization”, was initially developed in 1993 as a set of eight modules focusing on the vaccines included in the Expanded Programme on immunization...
World Health Organization (WHO)
The WHO Initiative for Vaccine Research organized a meeting jointly with the WHO Global Task Force on Cholera Control to examine the feasibility of a global stockpile for OCVs. Having major...
Teshome S et al.
Shanchol™, a WHO-prequalified oral cholera vaccine (OCV), has been used to control endemic cholera in Asia, as well as in emergencies and outbreaks elsewhere. The vaccine has not been used by...
World Health Organization (WHO)
The Controlled Temperature Chain Working Group (CTC) has recently developed a Strategic Roadmap for Priority Vaccines, which addresses supply and programmatic issues, aiming for CTC priority vaccines...
Marc Poncin et al.
Objective To describe the implementation and feasibility of an innovative mass vaccination strategy – based on single-dose oral cholera vaccine – to curb a cholera epidemic in a large urban...
Heyerdahl LW et al.
A reactive campaign using two doses of Shanchol Oral Cholera Vaccine (OCV) was implemented in 2016 in the Lake Chilwa Region (Malawi) targeting fish dependent communities. Three strategies for the...
Tomonori Nochi et al.
Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use of syringe and needle, mucosal vaccination is considered ideal for the global control...
Bekolo CE, van Loenhout JA, Rodriguez-Llanes JM, Rumunu J, Ramadan OP, Guha-Sapir D.
OBJECTIVE: To determine whether pre-emptive oral cholera vaccination reduces disease severity and mortality in people who develop cholera disease during an outbreak. METHODS: The study...
Mohammad Ali et al.
Background: Pregnancy increases the risk of harmful effects from cholera for both mothers and their fetuses. A killed oral cholera vaccine, Shanchol (Shantha Biotechnics, Hydrabad, India), can...
Lucy A Parker et al.
Shortages of vaccines for epidemic diseases, such as cholera, meningitis, and yellow fever, have become common over the past decade, hampering efforts to control outbreaks through mass reactive...
Amber Hsiao, Sachin N Desai, Vittal Mogasale, Jean-Louis Excler, Laura Digilio
Improving water and sanitation is the preferred choice for cholera control in the long-term. Nevertheless, vaccination is an available too l that has been shown to be a cost‒effective option for...
Mogasale V et al.
Cholera is transmitted through the fecal-oral route, and humans are the natural host. It is caused by the ingestion of O1 and less commonly O139 serogroups of the Vibrio cholerae bacterium and...
Saha A et al.
Cholera\'s impact is greatest in resource-limited countries. In the last decade several large epidemics have led to a global push to improve and implement the tools for cholera prevention and...
Kimberly M. Thompson et al.
Managing the dynamics of vaccine supply and demand represents a significant challenge with very high stakes. Insufficient vaccine supplies can necessitate rationing, lead to preventable adverse...
Dennis L. Chao et al.
In October 2010, a virulent South Asian strain of El Tor cholera began to spread in Haiti. Interventions have included treatment of cases and improved sanitation. Use of cholera vaccines would likely...
Mohammad Ali et al.
Cholera is an important public health problem worldwide. Although most cholera infections are not detected, large cholera outbreaks, such as those seen in Haiti,1 Viet Nam2 and Zimbabwe3 in recent...
Iza Ciglenecki et al.
The number of reported cholera cases worldwide, as well as the frequency and scale of cholera epidemics, are increasing [1]. Traditional prevention measures, which focus on provision of safe water...
Wilfredo R. Matias et al.
Background The bivalent whole-cell (BivWC) oral cholera vaccine (Shanchol) is effective in preventing cholera. However, evaluations of immune responses following vaccination with BivWC have been...
Nicholas C. Grassly et al.
The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in...
Jong-Hoon Kim et al.
Background Impact evaluation of vaccination programs is necessary for making decisions to introduce oral cholera vaccines (OCVs) in cholera-endemic countries. Methods We analyzed data to forecast...
Victoria Koski-Karell et al.
Since the beginning of the cholera epidemic in Haiti 5 years ago, the prevalence of this deadly water-borne disease has fallen far below the initial rates registered during its explosive outset....
Kelias Phiri Msyamboza et al.
Despite some improvement in provision of safe drinking water, proper sanitation and hygiene promotion, cholera still remains a major public health problem in Malawi with outbreaks occurring almost...
Firdausi Qadri et al.
A single-dose regimen of the current killed oral cholera vaccines that have been prequalified by the World Health Organization would make them more attractive for use against endemic and epidemic...
Teng- Jessica E, Thomson- Dana R, Lascher- Jonathan S, Raymond- Max & Ivers- Louise C
BACKGROUND: In mass vaccination campaigns- large volumes of data must be managed efficiently and accurately. In a reactive oral cholera vaccination (OCV) campaign in rural Haiti during an ongoing...
Verma et al.
Cholera is a major global public health problem and remains an important threat in almost every developing country, especially in areas where population overcrowding and poor sanitation are common,...
Jacqueline Deen et al.
Oral cholera vaccination could be deployed in a diverse range of situations from cholera-endemic areas and locations of humanitarian crises, but no clear consensus exists. The supply of licensed,...
Dang Duc Anh et al.
Killed oral cholera vaccines (OCVs) are available but not used routinely for cholera control except in Vietnam, which produces its own vaccine. In 2007–2008, unprecedented cholera outbreaks...
Rita Reyburn et al.
The outbreak of cholera in Zimbabwe intensified interest in the control and prevention of cholera. While there is agreement that safe water, sanitation, and personal hygiene are ideal for the long...
Christopher B. Nelson et al.
Cholera is an endemic and epidemic disease in Bangladesh. On 3 March 2013, a meeting on cholera and cholera vaccination in Bangladesh was convened by the Foundation Mérieux jointly with the...
Robert H. Hall & David A. Sack
Orally-administered cholera vaccine (OCV) has been increasingly examined as an additional tool to intervene against endemic and epidemic cholera. In 2013, short- and long-term field experience with...
M. Pastor et al.
Cholera remains a huge public health problem. Although in 1894, the first cholera vaccination was reported, an ideal vaccine that meets all the requirements of the WHO has not yet been produced....
Rania A. Tohme et al.
In 2013, the first government-led oral cholera vaccination (OCV) campaign in Haiti was implemented in Petite Anse and Cerca Carvajal. To evaluate vaccination coverage, barriers to vaccination, and...
Mauricio L Barreto et al.
Despite pronounced reductions in the number of deaths due to infectious diseases over the past six decades, infectious diseases are still a public health problem in Brazil. In this report, we discuss...
Ahmed M Khatib, Jacqueline Deen, Mohamed Saleh Jiddawi, John Clemens, Asish K Mukhopadhyay, Abdul A Saleh, Said Mohammed Ali, Thomas F Wierzba, Anna Lena Lopez, Marie-Paule Kieny, Maria Teresa Aguado, Raymond Hutubessy, Deok Ryun Kim, Lorenz von Seidlein, Mohammad Ali, Godwin Enwere, Kamala Thriemer, Benedikt Ley, Rita Reyburn, Ramadhan Hashim
Zanzibar, in east Africa, has been severely and repeatedly affected by cholera since 1978. The researchers assessed the effectiveness of oral cholera vaccination in high-risk populations in the...
John D. Clemens, Dipika Sur, Sujit K. Bhattacharya, Thomas F. Wierzba, Anna Lena Lopez, Jacqueline L. Deen, Byomkesh Manna, Suman Kanungo, Young Ae You, Mohammad Ali
BACKGROUND: Case-control studies have not been examined for their utility in assessing population-level vaccine protection in individually randomized trials. METHODS: We used the data of a...
Firdausi Qadri et al.
Cholera is endemic in Bangladesh with epidemics occurring each year. The decision to use a cheap oral killed whole-cell cholera vaccine to control the disease depends on the feasibility and...
Abdur Razzaque Sarker, Ashraful Islam Khan, Fahima Chowdhury, Amit Saha, Iqbal Ansary Khan, Firdausi Qadri, John David Clemens, Alejandro Cravioto, Ziaul Islam, Jahangir A.M. Khan
Cholera is a major global public health problem that causes both epidemic and endemic disease. The World Health Organization recommends oral cholera vaccines as a public health tool in addition to...
Mohammad Ali, et al.
PROBLEM: Field trials require extensive data preparation and complex logistics. The use of personal digital assistants (PDAs) can bypass many of the traditional steps that are necessary in a...