A novel measles outbreak control strategy in the Netherlands in 2013–2014 using a national electronic immunization register: A study of early MMR uptake and its determinants

Author: Laura M. Nic Lochlainn a,b,⇑, Tom Woudenberg a, Alies van Lier a, Irmgard Zonnenberg c, Marvin Philippi c, Hester E. de Melker a, Susan J.M. Hahné

Abstract

Background: During a large measles outbreak in the Netherlands in 2013–2014, infants aged 6–14 months living in municipalities with low (<90%) measles-mumps-rubella (MMR) coverage were individually invited for an early MMR using the national electronic immunization register, Præventis. We estimated uptake of early MMR prior to and during the 2013–2014 outbreak and assessed determinants for early MMR vaccination. Methods: We obtained vaccination records from Præventis, and defined early MMR as vaccination before 415 days (13 months) of age. A multi-level multivariable logistic regression model, restricted to infants with three diphtheria-pertussis-tetanus-polio (DPTP) vaccinations was used to examine the association between early MMR uptake and sex, parents’ country of birth, socioeconomic status (SES; at postcode level) and voting proportions for the Reformed Political Party (SGP; at municipal level), used as a proxy for religious objections towards vaccination. Results: In the 29 municipalities with low MMR coverage, uptake of early MMR was 0.5–2.2% prior to the outbreak. Between July 2013 and March 2014, 5,800 (57%) invited infants received an early MMR. Among infants with three DPTP, 70% received an early MMR. Only 1% of infants without prior DPTP received an early MMR. Lower early MMR uptake was associated with a higher SGP voter-ship (OR 0.89 per 5% increase, 95%CI 0.83–0.96), parents’ with unknown country of birth (OR 0.66 95%CI 0.47–0.93) and compared with very high SES, high SES had significantly lower early MMR uptake (OR 0.66 95%CI 0.50–0.87). Discussion: This is the first study describing use of Præventis during an outbreak and to assess determinants of early MMR uptake. More than half of invited infants obtained an early MMR. SES, parents’ with unknown country of birth and religious objections towards vaccination were found to be associated with lower early MMR uptake. In future outbreaks, these determinants could be used to tailor intervention strategies.

About

Type Journal article
Language English
Country Netherlands
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/28923422
Journal Vaccine
Volume 35 (2017)
Publisher Elsevier
Year 2017
Added by Hemanthi
Added on 10 October 2017 07:14:30
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