WHO Guidance: Vaccine Diluents - Revision 2015

Language
Published
2015

A vaccine diluent is the liquid mixed with a lyophilized (freeze-dried) vaccine in order to reconstitute the lyophilized vaccine and provide the final vaccine for administration. A vaccine diluent may be sensitive to heat or freezing, and may require transportation and storage in the cold chain. This guidance note outlines the proper handling and use of vaccine diluent, including, but not limited to, critical steps for reconstituting vaccines safely.