Mycobacterium bovis (BCG) bacteremia in immunocompetent neonates following vaccination

Author: Somsak Thamthitiwat et al.
Category: Service delivery


We describe four cases of Mycobacterium tuberculosis complex bacteremia diagnosed in immunocompetent neonates, who presented with high fevers and/or jaundice within 72 h after Bacille Calmette-Guérin (BCG) vaccination. All neonates were hospitalized, and none received anti-mycobacterial therapy. All recovered completely and remain healthy 2–3.5 years later. Genotyping of one available isolate identified the pathogen as Mycobacterium bovis BCG. The similar clinical presentations and close temporal association between BCG vaccination and illness suggest that all four neonates likely had BCG bacteremia. BCG bacteremia shortly following vaccination among healthy neonates has not been previously described and merits further study to determine its frequency and clinical significance.


Type Journal article
Language English
Country Not Specified
Journal Vaccine
Volume 29
Year 2011
Disease Tuberculosis
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Added on 24 November 2015 06:48:09
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