Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque

Author: Chris Edens, Naomi C. Dybdahl-Sissoko, William C. Weldon, M. Steven Oberste, Mark R. Prausnitz

Abstract

The phased replacement of oral polio vaccine (OPV) with inactivated polio vaccine (IPV) is expected to significantly complicate mass vaccination campaigns, which are an important component of the global polio eradication endgame strategy. To simplify mass vaccination with IPV, we developed microneedle patches that are easy to administer, have a small package size, generate no sharps waste and are inexpensive to manufacture. When administered to rhesus macaques, neutralizing antibody titers were equivalent among monkeys vaccinated using microneedle patches and conventional intramuscular injection for IPV types 1 and 2. Serologic response to IPV type 3 vaccination was weaker after microneedle patch vaccination compared to intramuscular injection; however, we suspect the administered type 3 dose was lower due to a flawed pre-production IPV type 3 analytical method. IPV vaccination using microneedle patches was well tolerated by the monkeys. We conclude that IPV vaccination using a microneedle patch is immunogenic in rhesus macaques and may offer a simpler method of IPV vaccination of people to facilitate polio eradication.

About

Type Journal article
Language English
Country Not Specified
Link http://www.sciencedirect.com/science/article/pii/S0264410X1500184X
Journal Vaccine
Volume 33
Publisher Elsevier
Year 2015
Disease , Inactivated polio vaccine , Microneedle patch , Poliomyelitis , Rhesus macaque , Sharps Waste
Added by Marilyn Kelly
Added on 23 February 2017 10:13:42
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