Yellow Fever in Africa: estimating the burden of disease and impact of mass vaccination from outbreak and serological data

Author: Garske T1, Van Kerkhove MD1, Yactayo S2, Ronveaux O3, Lewis RF4, Staples JE5, Perea W2, Ferguson NM1; Yellow Fever Expert Committee

Abstract

Yellow fever is a vector-borne disease affecting humans and non-human primates in tropical areas of Africa and South America. While eradication is not feasible due to the wildlife reservoir, large scale vaccination activities in Africa during the 1940s to 1960s reduced yellow fever incidence for several decades. However, after a period of low vaccination coverage, yellow fever has resurged in the continent. Since 2006 there has been substantial funding for large preventive mass vaccination campaigns in the most affected countries in Africa to curb the rising burden of disease and control future outbreaks. Contemporary estimates of the yellow fever disease burden are lacking, and the present study aimed to update the previous estimates on the basis of more recent yellow fever occurrence data and improved estimation methods.

About

Type Journal article
Language English
Country Not Specified
PubMed URL http://www.ncbi.nlm.nih.gov/pubmed/24800812
Journal PLos Med
Volume 2014 May 6;11(5):e1001638. doi: 10.1371/journal.pmed.1001638
Year 2014
Added by Hemanthi
Added on 25 July 2018 04:06:34
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