1.1 Risk to vaccines

The introduction of new vaccines in the EPI programmes has led to an exponential increase of both the value and volume of vaccines. The new vaccines are relatively expensive, require more cold storage capacity and most of them are both heat and freeze sensitive and should be stored between +2°C and + 8°C. These factors intensify the demands on the Immunization Supply Chain as they impact many areas; e.g. increased number of journeys to pick up from the airport, increased required cold truck capacity, increased cold chain capacity requirement at all levels, increased need to manage the vaccine supply chain and increased risk as the value of vaccines in storage increases. This creates huge challenges for the EPI programmes and the need for strong logistics systems.

The graph below from the EVM latest report shows the planned increases between 2015 and 2020 alone.

Storage requirements of vaccinationEVM

Source: EVM Global Data Analysis report

Even though the value of vaccines has increased exponentially, investments in the cold chain have been lagging behind, exposing vaccines to greater risks. If vaccines are not stored at the right storage temperature of (2-8°C), this can result in damaged vaccines, unprotected children and wasted country/donor investment. 

Many exposures happen in static storage; this is why monitoring and managing CCE temperature is critical. Accurate temperature monitoring data can act as a proxy of the cold chain status and pinpoint equipment issues that need to be addressed.

Obsolete and malfunctioning equipment, included in cold chain capacity estimates can create a gap between estimated cold chain capacity and effective cold chain capacity. This dichotomy can endanger the vaccines and it is therefore critical for EPI programmes to get actionable data on the actual status of the cold chain and know the real capacity. 

A root cause analysis can help identify the main bottlenecks and challenges of the current system as per the example of the figure below. Being aware of the traps is a first step towards being able to avoid them.

 

Source: Claire Frijs-Madsen, Unicef 

 

WHO Immunization in practice provides an overview of the recommended practices and clear instructions for temperature surveillance for vaccine handling as well as a list of recommended corrective actions to be taken by health workers when the refrigerator’s temperatures are out of the recommended range below +2°C or above +8°C. Temperature monitoring studies (see related resources) provide an evaluation of the cold chain and show that the main causes for equipment failures leading to temperature excursions can vary significantly from one country to another and range from power outage, thermostat improperly adjusted, failed compressors in aging refrigerators to flat batteries due to dirty panels for solar and more. Conducting a Temperature study can help pinpoint what segments of the cold chain represent the major challenges and risks and can help countries set their priorities when improving their temperature monitoring.

The risks inherent to the possible solutions for temperature monitoring must be assessed as well: e.g. for 30DTR, the risk of the batteries expiring before new supplies of devices are available, the risk of the data not being used apart from the daily reading by health workers, for RTM, the risk of using temporary SIM cards that run out of cash, the risk of not being able to manage the data.

Countries embarking on a project of implementing systematic temperature monitoring need a good understanding of where the focus needs to be and where the risk is highest. To minimize these risks a system is needed that can systematically detect, escalate and address issues with CCE. 

Related Resources

English

Title Author Year Type Language
Appendix 01 Checklist Temperature Monitoring Studies UNICEF 2018 Document English
Temperature Monitoring Study Data Analysis Tool UNICEF 2018 Tool English
Appendix 12 Instruction sheet UNICEF 2018 Document English
Appendix 07 Interview Recording Template UNICEF 2018 Document English
Appendix 10 Master Tracking Form UNICEF 2018 Document English
Appendix 11 Monitoring Form UNICEF 2018 Document English
Appendix 15 Dissemination Presentation UNICEF 2018 Document English
Appendix 14 Data Analysis Tool Guide UNICEF 2018 Document English
Appendix 16 TMS Report UNICEF 2018 Document English
Appendix 09 Data sharing Agreement UNICEF 2018 Document English
Appendix 05 Workshop Agenda UNICEF 2018 Document English
Appendix 08 Country Protocol UNICEF 2018 Document English
Appendix 02 Consultant Terms of Reference UNICEF 2018 Document English
Appendix 06 Workshop Overview Presentation Template UNICEF 2018 Presentation English
Temperature Monitoring Study Handbook UNICEF 2018 Document English

French

Title Author Year Type Language
Annexe 12 Feuille d'instructions - Etudes de températures UNICEF 2018 Document French
Annexe 11 Feuille de suivi - Etudes de temperatures UNICEF 2018 Document French
Annexe 10 Matrice des circuits - Etudes de températures UNICEF 2018 Document French
Annexe 09 Accord de partage des données - Etudes de températures UNICEF 2018 Document French
Annexe 08 Protocole spécifique au pays, Etudes de températures UNICEF 2018 Document French
Annexe 07 Notes d'interviews, Etudes de températures UNICEF 2018 Document French
Annexe 05 Agenda d'atelier de présentation UNICEF 2018 Document French
Annexe 01 Liste de controle, Etudes de températures UNICEF 2018 Document French
Manuel pour les études de températures UNICEF 2018 Document French
Annexe 02 Termes de reference du consultant - Etudes de Temperatures UNICEF 2018 Document French
Outil d'analyse des données pour les études de températures UNICEF 2018 Tool French
Annexe 15 Presentation des résultats - Etudes de températures UNICEF 2018 Presentation French
Annexe 14 Guide de l'outil d'analyse de températures UNICEF 2018 Document French
Annexe 16 Rapport Final - Etudes de températures UNICEF 2018 Document French
Annexe 06 Présentation Atelier d'introduction - Etudes de températures UNICEF 2018 Document French

 

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