Controlled temperature chain - technical resources

Togo 28nov2014 34

The controlled temperature chain (CTC) is an innovative approach to vaccine management that allows vaccines to be kept at temperatures outside of the traditional cold chain of +2°C to +8°C for a limited period of time under monitored and controlled conditions, as appropriate to the stability of the antigen. A CTC typically involves a single excursion of the vaccine into ambient temperatures not exceeding +40°C and for a duration of a specific number of days, just prior to administration.

This page provides a list of resources related to CTC, as well as materials developed by the CTC Working Group. The aim is to raise CTC awareness among multi-sector stakeholders and industry; engage more partners through the promotion of a common vision and strategy around CTC; encourage a constructive dialogue with manufacturers on the need for more vaccine innovations and their willingness to consider CTC labelling for new or existing vaccines; increase country uptake of CTC implementation during immunization campaigns to increase vaccine coverage and generate more data on CTC. Resources are orgaised by category:

 

Publications

Title Author Year Type Language
Controlled Temperature Chain: Strategic Roadmap for Priority Vaccines WHO Controlled Temperature Chain 2017 Document English
Delivering MenAfriVac using the controlled temperature chain approach PATH, World Health Organization 2013 Document English
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns : adaptation guide and facilitators guide World Health Organization 2013 Document English
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns: guidance for immunization programme decision-makers and managers World Health Organization Document English
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns : training module for organizing immunization sessions World Health Organization 2013 Document English
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à températtrôlée (CTC) pendant les campagnes - Guide d'adaptation et guide du formateur World Health Organization 2013 Document French
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à température contrôlée (CTC) pendant les campagnes - Guide à l'intention des décideurs et des administrateurs des programmes de vaccination WHO 2013 Document French
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à température contrôlée (CTC) pendant les campagnes - Module de formation pour l'organisation de séances de vaccination WHO 2013 Document French
What is a controlled temperature chain (CTC)? World Health Organization 2015 Document English

 

Journal articles

Title Author Year Type Language
A cluster randomized non-inferiority field trial on the immunogenicity and safety of tetanus toxoid vaccine kept in controlled temperature chain compared to cold chain Aitana Juan-Giner, Camille Domicent, Céline Langendorf, Martha H. Roper, Paul Baoundoh, Florence Fermone, Primitive Gakimad, Simona Zipursky, Mbaihol 2014 Journal article English
An economic evaluation of the controlled temperature chain approach for vaccine logistics: evidence from a study conducted during a meningitis A vaccine campaign in Togo Mvundura et all 2017 Journal article English
Can thermostable vaccines help address cold-chain challenges? Results from stakeholder interviews in six low- and middle-income countries Debra D. Kristensen et al. 2016 Journal article English
Economic benefits of keeping vaccines at ambient temperature during mass vaccination: the case of Meningitis A vaccine in Chad Patrick Lydon et al. 2014 Journal article English
Extending supply chains and improving immunization coverage and equity through controlled temperature chain use of vaccines Anna-Lea Kahn et al. 2017 Journal article English

 

Advocacy

Title Author Year Type Language
CTC FAQs Controlled Temperature Chain Team 2016 Presentation English
Infographique CTC WHO 2015 Document French
Questions fréquentes CTC WHO 2015 Document French