Post 01012E : HIB AND ROTAVIRUS VACCINATION 17 November 2006
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In Post 00987E the resume of an article discussed the effectiveness
of Hib vaccine introduction into routine EPI in Kenya. The following
link will lead you to a full article on the same topic, but in Malawi
this time, to be published soon in "Vaccines".
http://www.technet21.org/pdf_file/MalawiHibVac.pdf
This article was also added to the list of background documents on
our site : http://www.technet21.org/backgrounddocs.html
If you visit the page and find any link not working, please inform
TechNet. If you know any recent scientific article on any topic in
the field of immunization that would add to our still short list of
technical background information, please also inform TechNet and give
precise references. There is a constraint though, it should be
accessible electronically without any fee.
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Below is the resume of an article on rotavirus immunization published
in the Journal of Infectious Diseases.
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Projected cost-effectiveness of rotavirus vaccination for children in Asia.
By Podewils LJ, Antil L, Hummelman E, Bresee J, Parashar UD, Rheingans R.
Respiratory and Enteric Viruses Branch, Division of Viral and
Rickettsial Diseases, National Center for Infectious Diseases,
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
mailto:[email protected]
BACKGROUND:
New rotavirus vaccines may soon be licensed, and decisions regarding
implementation of their use will likely be based on the health and
economic benefits of vaccination.
METHODS:
We estimated the benefits and cost-effectiveness of rotavirus
vaccination in Asia by using published estimates of rotavirus disease
incidence, health care expenditures, vaccine coverage rates, and
vaccine efficacy.
RESULTS:
Without a rotavirus vaccination program, it is estimated that 171,000
Asian children will die of rotavirus diarrhea, 1.9 million will be
hospitalized, and 13.5 million will require an outpatient visit by
the time the Asian birth cohort reaches 5 years of age. The medical
costs associated with these events are approximately 191 million US
dollars; however, the total burden would be higher with the inclusion
of such societal costs as lost productivity. A universal rotavirus
vaccination program could avert approximately 109,000 deaths, 1.4
million hospitalizations, and 7.7 million outpatient visits among
these children.
CONCLUSIONS:
A rotavirus vaccine could be cost-effective, depending on the income
level of the country, the price of the vaccine, and the
cost-effectiveness standard that is used. Decisions regarding
implementation of vaccine use should be based not only on whether the
intervention provides a cost savings but, also, on the value of
preventing rotavirus disease-associated morbidity and mortality,
particularly in countries with a low income level (according to 2004
World Bank criteria for the classification of countries into income
groups on the basis of per capita gross national income) where the
disease burden is great.
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