POST 01021E : T SERIES VACCINE EFFICACY 6 December 2006
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Jedeth Mamora (mailto:
[email protected]) from UNICEF in Indonesia,
is asking questions on the efficacy of T series vaccine. I wonder how
the search was made on the WHO site but I would suggest the WHO
modules "Immunological Basis for Immunization" One of the eight
modules is on tetanus and I believe that answers can be found there, at
http://www.who.int/vaccines-documents/DoxTrng/h4tibi.htm
Can other members make any other suggestion and/or provide answers?
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Dear Technet 21,
I am curious and a little bit confused to know about the length of
effectivity of DPT, DT and TT vaccines. I have read some of the
related vaccination literatures, which merely mention the periods of
administration of the said vaccines without explaning deeply on the
length of effect of vaccines in the body (immunology). For example:
DPT1-3, given to a baby age 6, 10 and 14 weeks old; DT at grade 1 to
3 primary school and again for WRA roughly age between 15 to 45 years
to get TT1-TT5; a need of DT booster at every 5 to 10 years
periodically regardless of the receiver age and gender.
So, I want to know how is this Tetanus vaccine effectively work in
the immune body system, how long the memory T cell retains the
Tetanus ID before it forgets, and why do so many scholarly
literatures (I refer it to reliable websites such as: Mayo Clinic,
UNICEF, WHO , John Hopkins, and PATH) did not mention a sort of
'standard' of quantity of tetanus vaccine should a person receive
from baby to old age. To make it clearer if a woman receives TT1-TT5,
the length of protection of the vaccine for the body is 30 years (or
what Indonesian translation said if TT5 then it will protect the body
forever or as long as the person lives.) How to justify if a DT
booster has to be administered every 5 to 10 years regardless of
someone's age and gender. Both TT and DT contains Tetanus vaccine,
but why has to be different, is not TT5 protection level of 30 years,
why need another booster? Do TT differ from DT and DPT in terms of
doses administered to the body which may give varied effectivity?
I need to understand how this particular Tetanus vaccine works. How
is it related with the prevailing bacteria Clostridium tetani in soil
that never could be eliminated compared to other VPD's such as Polio
and Measles?
If you could not give much answers, perhaps someone could refer me to
other credible website (s) that could give answer to most of the questions.
Thank you and kind regards,
JJ
Jedeth Jenefa Mamora, MPH
EPI Asistant Project Officer
Health & Nutrition Dept
Banda Aceh Zone Office
Indonesia
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