mercredi 5 novembre 2003
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POST 00613E : SINGLE-DOSE VERSUS MULTI-DOSE 5 November 2003 ____________________________ Attached is a very interesting article, "Single-dose versus multi-dose vaccine vials for immunization programmes in developing countries" by Paul K. Drain, Carib M. Nelson and John S. Lloyd, from PATH. Recently published in the "Bulletin of the World Health Organization, volume 81", it discusses differences between single-dose and multi-dose formats and their respective programmatic and economic benefits. Based on this discussion it offers recommendations for making the most appropriate selection. Below is the abstract which is also presented in French and Spanish at the end of the article. If you have any problem downloading the article it can also be accessed from the WHO site at : http://www.who.int/bulletin/volumes/81/10/en/Drain1003.pdf ____________________________ Excessive vaccine wastage and safety concerns have prompted the international health community to develop and supply vaccines in formats other than the standard multi-dose vial. This article presents a programmatic and economic comparison of the major differences between the multi-dose vials and single-dose formats used for immunization services in developing countries. Multi-dose vials, in general, sell at a lower per-dose price and occupy less cold-chain capacity than single-dose formats. However, higher wastage rates may offset these benefits, especially for more expensive vaccines. Single-dose formats offer several important programmatic benefits, such as increased vaccination opportunities and improved vaccine safety. One single-dose format, the prefilled auto-disable (AD) device, provides additional injection safety and convenience features because it physically combines the vaccine and AD syringe. Selecting the appropriate vaccine presentation will depend on many factors. However, multi-dose vials are likely to be most appropriate for cheaper vaccines and in settings where cold-chain storage capacity is restricted. Single-dose formats will be most appropriate for more expensive vaccines and where there are problems with unsafe injection practices. Prefilled AD injection devices will be particularly useful in expanding outreach services while eliminating the possibility of needle reuse. ----------------------------------------------------------------------------------- Visit the TECHNET21 Website at http://www.technet21.org You will find instructions to subscribe, a direct access to archives, links to reference documents and other features. ______________________________________________________________________________ To UNSUBSCRIBE, send a message to : mailto:[log in to unmask] Leave the subject area BLANK In the message body, write unsubscribe TECHNET21E ______________________________________________________________________________ The World Health Organization and UNICEF support TechNet21. The TechNet21 e-Forum is a communication/information tool for generation of ideas on how to improve immunization services. It is moderated by Claude Letarte and is hosted in cooperation with the Centre de internationale en , Canada (http://www.ccisd.org) ______________________________________________________________________________ ##text##
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