Dear colleagues,
Here is a rather technical question: what to do with a "non freeze-sensitive" vaccine after exposure to freezing? The ultimate objective of my question is to refine and validate operational guidance for field workers.
In the case of the "freeze-sensitive" vaccines (commonly HepB, penta, PCV, TT), the operational guidance is rather clear -- that vaccines exposed to freezing temperature should be tested (with a shake test) and discarded if they don't pass the test (vials frozen solid can be discarded immediately). The shake test only works with vaccines with an aluminum adjuvant (perhaps others compounds too), a component that classifies the vaccines as "freeze-sensitive" to start with if I am not mistaken.
Then, there are vaccines for which the shake test "does not work"; usually these vaccines are not classified as freeze-sensitive -- nonetheless their manufacturer label might ask for a storage between 2-8°C. Thus the question:
If a field worker finds a vial from such vaccine that is frozen solid (an unfortunate but not impossible situation), should the vaccine be discarded?
Thanks you in advance for your comments,
Yann
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