Article de revue
Waning protection after fifth dose of acellular pertussis vaccine in children
The researchers compared 277 children, 4 to 12 years of age, who were PCR-positive for pertussis with 3318 PCR-negative controls and 6086 matched controls. PCR-positive children were more likely to have received the fifth DTaP dose earlier than PCR-negative controls (P<0.001) or matched controls (P=0.005). Comparison with PCR-negative controls yielded an odds ratio of 1.42 (95% confidence interval, 1.21 to 1.66), indicating that after the fifth dose of DTaP, the odds of acquiring pertussis increased by an average of 42% per year.
Auteurs
Langues
- Anglais
Année de publication
2012
Journal
N Engl J Med
Volume
11
Type
Article de revue
Catégories
- Prestation de services
Maladies
- Diphtérie
Pays
- États-Unis
Mots-clés
- Coverage monitoring
- Performance monitoring
Régions de l'OMS
- Région des Amériques