Article de revue
Clinical manifestations of leprosy after BCG vaccination: An observational study in Bangladesh
An unexpectedly high proportion of healthy contacts of leprosy patients presented with PB leprosy within 12 weeks after receiving BCG vaccination, possibly as a result of boosted cell-mediated immunity by homologues of Mycobacterium leprae antigens in BCG. Various immunological mechanisms could underlie this phenomenon, including an immune reconstitution inflammatory syndrome (IRIS). Further studies are required to determine whether BCG vaccination merely altered the incubation period or actually changed the course of the infection from self-limiting, subclinical infection to manifest disease.
Auteurs
Langues
- Anglais
Année de publication
2015
Journal
Vaccine
Volume
13
Type
Article de revue
Catégories
- Prestation de services
Maladies
- Tuberculose
Pays
- Bangladesh
Mots-clés
- Health promotion
Régions de l'OMS
- Région de l'Asie du Sud-Est