Background: A number of vaccines were recommended by many countries for pregnant persons to reduce the risk associated with COVID 19 infection in pregnancy. Despite this potential of the vaccine, uptake remains challenging among pregnant women especially in low-income countries. Hence, this study assessed the influence of some factors on the uptake of COVID- 19 vaccine among pregnant women.

Method: A structured tool which elicited information on participants' background, knowledge, attitude and the outcome of interest 'ever vaccinated for COVID-19' at any point in time were used to interview the pregnant women from three facilities in the Greater Accra Region, Ghana.

Findings: A total of 401 pregnant women were recruited consecutively from all three facilities. Most of the women were between 25 and 34 years old (55.8 %), married (75.6 %), in their third trimester of pregnancy (41.4 %) and had attained junior or senior high school education (61.1 %). The frequency of COVID-19 vaccine uptake among participants was 41.9 %. Vaccination was higher among women with a college or university education (AOR = 3.35, 95 % CI = 1.48-7.54), older women aged 35-49 years (AOR = 1.82, 95 % CI = 0.90-3.66), and women who believed the COVID-19 vaccine in pregnancy will reduce their baby's risk (AOR = 3.02, 95 % CI = 1.37-6.63).

Discussion: The study recommends the need for vaccination education campaign among pregnant women with more efforts targeted at those with low level of education and younger (below 35 years old).