Immunization information systems (IISs) are confidential-

computerized information systems that collect and consolidate

vaccination data from multiple health-care providers- generate

reminder and recall notifications- and assess vaccination coverage

within a defined geographic area. A CDC program goal for 2010 is to

achieve >or=95% participation in an IIS (defined as having two

or more recorded vaccinations) among children aged <6 years. To

monitor progress toward this goal- CDC annually surveys

immunization grantees in 50 states- five cities- and the District

of Columbia- using the Immunization Information Systems Annual

Report (IISAR). All 56 grantees were asked to complete the IISAR/

52 did so for 2008. This report highlights results from the 2008

IISAR- which indicated that 75% of all U.S. children aged <6

years (approximately 18 million children) participated in an IIS in

2008- an increase from 65% in 2006. The majority of grantees (82%)

reported that their IIS had the capacity to track vaccinations for

persons of all ages- compared with 70% in 2006. Data-quality

measures of timeliness and completeness indicated that in 2008- 67%

of IIS data were received and processed within 30 days of vaccine

administration- and data were reported for six of 17 core data

elements in >or=90% of IIS records (both measures are similar to

2006 results). Increased provider use of electronic health record

systems can benefit IISs and their users by producing immunization

records that are more timely and complete.