Article de revue

Safety and immunogenicity of a primary series of Sabin-IPV with and without aluminum hydroxide in infants

Pauline Verdijk, Nynke Y. Rots, Monique G. C. T. van Oijen, William C. Weldon, M. Steven Oberste, Hiromasa Okayasu, Roland W. Sutter, Wilfried A. M. Bakker

Safety and immunogenicity of Sabin-IPV (sIPV) was evaluated in a double-blind, randomized, controlled, dose-escalation trial in the target population. Healthy infants (n=20/group) aged 56-63 days, received a primary series of three intramuscular injections with low-, middle- or high-dose sIPV with or without aluminum hydroxide or with the conventional IPV based on wild poliovirus strains (wIPV). Virus-neutralizing titers against both Sabin and wild poliovirus strains were determined before and 28 days after three vaccinations.

Auteurs

Langues

  • Anglais

Année de publication

2014

Journal

Vaccine

Volume

9

Type

Article de revue

Catégories

  • Vaccins et dispositifs d'administration

Maladies

  • Polio

Mots-clés

  • Essais de vaccin

Ajouté par: Moderator

Ajouté le: 2015-11-21 10:37:01

Consultations: 2262

Liens

URL PubMED

http://www.ncbi.nlm.nih.gov/pubmed/25043278

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