Article de revue

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial

Nadine G. Rouphael, Michele Paine, Regina Mosley, Sebastien Henry, Devin V. McAllister, Haripriya Kalluri, Winston Pewin, Paula M. Frew, Tianwei Yu, Natalie J. Thornburg, Sarah Kabbani, Lilin Lai, Elena V. Vassilieva, Ioanna Skountzou, Richard W. Compans, Mark J. Mulligan, Mark R. Prausnitz

Microneedle patches provide an alternative to conventional needle-and-syringe immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety. We describe safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable microneedle patch vaccination against influenza.

Auteurs

Langues

  • Anglais

Année de publication

2017

Journal

The Lancet

Volume

390

Numéro

10095

Type

Article de revue

Catégories

  • Vaccins et dispositifs d'administration

Maladies

  • Grippe

Mots-clés

  • Sécurité des injections

Ajouté par: Marilyn Kelly

Ajouté le: 2017-06-28 07:03:42

Consultations: 1441

URL PubMED

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30575-5/fulltext?elsca1=tlpr

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