Article de revue
Vaccine design reaches the atomic level
The genetic diversity of pathogens presents a challenge to the development of broadly effective vaccines. In this issue, Scarselli et al. combine atomic-level structural information with genomics and classical vaccinology to design a single immunogen that elicits protective immunity against more than 300 natural variants of the bacterial pathogen meningococcus B. This accomplishment provides a glimpse of the power of structure-based vaccine design to create immunogens capable of eliciting protective responses against genetically diverse pathogens.
Auteurs
Langues
- Anglais
Année de publication
2011
Journal
Sci. Transl. Med.
Volume
91
Type
Article de revue
Catégories
- Vaccins et dispositifs d'administration
Mots-clés
- Introduction de nouveaux vaccins
