Article de revue
Validation of the shake test for detecting freeze damage to adsorbed vaccines
Objective: To determine the validity of the shake test for detecting freeze damage in aluminium-based, adsorbed, freeze-sensitive vaccines.
Methods: A double-blind crossover design was used to compare the performance of the shake test conducted by trained health-care workers (HCWs) with that of phase contrast microscopy as a “gold standard”. A total of 475 vials of 8 different types of World Health Organization prequalified freeze-sensitive vaccines from 10 different manufacturers were used. Vaccines were kept at 5 °C. Selected numbers of vials from each type were then exposed to −25 °C and −2 °C for 24-hour periods.
Langues
- Anglais
Année de publication
2010
Journal
Bulletin of the World Health Organization
Volume
88
Type
Article de revue
Catégories
- Chaîne d'approvisionnement
Organisations
- Organisation Mondiale de la Santé (OMS)
Mots-clés
- Gestion de vaccin
Critère GEV
- E8 Gestion des vaccins
