POST 01096E : IPV EFFICACY 23 May 2007
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In the perspective of polio eradication and cessation of OPV vaccination, you will be interested in the following article :
"Randomized, Placebo-Controlled Trial of Inactivated Poliovirus Vaccine in Cuba" by The Cuba IPV Study Collaborative Group, published in the New England Journal of Medicine, Volume 356:1536-1544, Number 15, April 12, 2007.
Authors say : "After poliomyelitis has been eradicated, access to live polioviruses will be highly restricted and the use of oral poliovirus vaccine (OPV) will probably be discontinued. Countries using OPV must decide whether to switch to inactivated poliovirus vaccine (IPV) or stop polio vaccination. Because data on the immunogenicity of IPV in tropical developing countries are limited, we conducted a randomized, controlled trial of IPV in Cuba."
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The institutions of the Cuba IPV Study Collaborative Group and their representatives are Miguel Galindo, M.D., Cuban Ministry of Public Health, Havana; Pedro Más Lago, M.D., Ph.D., Pedro Kourà Institute for Tropical Medicine, Havana; Victor Cáceres, M.D., M.P.H., Centers for Disease Control and Prevention, Atlanta; Mauricio Landaverde, M.D., Pan American Health Organization, Washington, DC; and Roland Sutter, M.D., M.P.H.&T.M., World Health Organization, Geneva.
You may wish to review the question of OPV cessation and the following two-page short article provides a good overview.
OPV Cessation--the Final Step To a "Polio-Free" World, by R. Bruce Aylward, Roland W. Sutter, David L. Heymann, published in Science, 28 October 2005: Vol. 310. no. 5748, pp. 625 - 626.