POST 01346E: WILD POLIO VIRUS 1,2 & 3 AND VAPP REQUIRE AN EFFECTIVE VACCINE FOR ERADICATION FOLLOW-UP ON POSTS 01339E, 01341E, 013342E, 01343E, 01344E & 01345E
5 NOVEMBER 2008
******************************************
Dear Editor,
As per your suggestion I looked up the web-page: "Weekly Update"and found a large but interesting table "Wild Polio Virus List". I have copied the "total" columns and files below.
What strikes you when studying carefully this table, is what has happened in 2007 and 2008:
1. In 2007 the cases of Wild Polio 1 went very much down, but unfortunately the cases of Wild Polio 3 went up.
2. In 2008 the number of cases of both Polio Wild 1 and Polio Wild 3 have been high.
You get the impression that a vaccine against Wild Polio 1 is not that good for eradicating Polio Wild 3.
Do we have a vaccine that is equally good for all strains of polio?
Do we not have an epidemiologist between the readers of Technet Forum who can explain this puzzle?
2000
2001
2002
2003
2004
2005
2006
2007
Jan-end Oct.
2007
2008
Total Polio cases
719
483
1918
784
1255
1979
1997
1315
669
1431
Wild type 1
349
1744
555
1045
1716
1666
321
236
853
Wild type 3
134
174
229
210
263
331
994
433
578
Number of countries
23
15
9
15
18
16
17
12
11
15
Best regards,
Mogens Munck ([[email protected]][email protected][/email]) --------
Robert Steinglass shares with us the Indian Academy of Pediatrics’ (IAP) position paper on polio and RI. Many thanks.
Extracts from the paper
Universal Immunization Program and Polio Eradication in India
While India had the potential to be the leader of Universal Immunization Programme (UIP) and polio eradication in the SE Asia Region, the national policies, strategies, tactics and achievements have not matched that potential. On the contrary, India’s UIP remains one of the weakest and India is the only country in the Region with no effective measles control program and the only one that did not achieve polio eradication by the year 2000. We believe there is a nexus between poorly performing UIP and the delays to achieve polio eradication. We also believe that with political will and well-designed action plan India can rapidly improve UIP. A high-performing UIP will be essential to sustain polio eradication in the long term after interruption of transmission of wild polioviruses is achieved. ...
While PEI and UIP are intimately intertwined, it was indeed unfortunate that PEI was virtually de-linked from UIP in terms of technical issues while burdening UIP managers with additional workload. The long term sustainability of PEI and the protection of the enormous investments made to date for PEI will rest in future on an efficiently functioning UIP. ...
Scientific studies in India had shown clearly that the protective efficacy (vaccine efficacy, VE) of tOPV was very low for types 1 and 3 but satisfactory for type 2. Large numbers of children developed polio in spite of 3 doses of tOPV every year. Indian studies had also shown very high efficacy of IPV for all three types (1-2). ...
Countries that used IPV achieved complete eradication straightaway, but countries that eradicated wild viruses using OPV had to go through a second phase to eliminate vaccine viruses, for which many have switched to IPV from OPV from the 1980s onwards. ...
The GoI embarked on the mission of PEI as if eradication should be achieved first, and improvement of UIP could be attempted later. It will be extremely unwise to postpone the reconstruction of the damaged UIP system – a likely temptation in view of the fact that WPV types 1 and 3 may be eradicated using mOPVs. ...
The need for high vaccination coverage with all UIP vaccines pre-existed the era of PEI. The importance and need for efficient UIP will outlive PEI. The need to monitor the progress of control of diseases under UIP has not been realized; one element of the poor performance of UIP is precisely this lack of monitoring. Targeting polio for eradication before controlling diphtheria, pertussis and measles would have been justified only if high UIP vaccination coverages were achieved against these diseases. ... The full paper is attached.
Post generated using Mail2Forum (http://www.mail2forum.com)
##text##
Il n'y a pas encore de réponse à ce message.