Malaria vaccine introduction – technical resources

Jenny Walldorf

In October 2023, WHO recommended the programmatic use of malaria vaccines for the prevention of P. falciparum malaria in children living in malaria endemic areas, prioritizing areas of moderate and high transmission.

This page provides a summary of the current global recommendations, evidence and programmatic considerations for malaria vaccine introduction into national immunization programmes – including implementation guidance, demand promotion and communications in support of malaria vaccine uptake, health worker generic training resources (to adapt for country use) and a series of technical references, publications and information resources.

Lessons learned from country-level pilot experiences (in Ghana, Kenya and Malawi) are also integrated into guidance to further inform planning and implementation. The content and guidance on this page are curated and maintained by the WHO Department of Immunization, Vaccines, and Biologicals.

The following resources aim to support immunization programme decision-makers and managers, immunization partners and stakeholders, and national malaria control programmes (NMCPs) in the following areas:

Resources for decision-making

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Global guidance 

Malaria vaccine - WHO position paperWorld Health Organization (WHO)2024GuidanceAnglais, Français
WHO Guidelines for malariaWorld Health Organization (WHO)2022GuidanceArabe, Anglais, Français, Espagnol
WHO prequalification - Mosquirix (RTS,S/AS01)World Health Organization (WHO)2022GuidanceAnglais
WHO Prequalification - R21 MalariaWorld Health Organization (WHO)2023GuidanceAnglais

Evidence reports and publications

Full evidence report on the R21/Matrix-M malaria vaccineWorld Health Organization (WHO)2023ReportAnglais
Full evidence report on the RTS,S/AS01 malaria vaccineWorld Health Organization (WHO)2021ReportAnglais
Malaria Vaccine Evidence-to-Recommendations Framework: R21/Matrix-M2023ReportAnglais
Malaria vaccine GRADE Evidence table2023ReportAnglais

Q&A and infographics on guidance and evidence 

Malaria vaccine - questions and answersWorld Health Organization (WHO)GuidanceAnglais, Français
Malaria vaccine: Questions and answers on supply, price, and market shapingUNICEFGuidanceAnglais, Français
WHO news release - R21/Matrix-M malaria vaccine recommendationWorld Health Organization (WHO)2023GuidanceAnglais, Français

Resources for planning 

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Implementation guidance 

Resources for demand promotion and communications 

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The tools listed below offer practical and adaptable guidance on how to: carry out planning and coordination, gather and use behavioural data to inform interventions, support health worker interactions, engage with communities, promote accurate information, and connect malaria vaccination activities to broader integrated approaches for strengthening vaccination programmes and malaria prevention and control. 

0.1 Key messages on malaria vaccination for health workers and caregiversWorld Health Organization (WHO)2023GuidanceAnglais
0.2 Messages clés sur la vaccination antipaludiqueWorld Health Organization (WHO)2023GuidanceFrançais
1.1. Promoting Demand for Malaria Vaccination: A Planning GuideWorld Health Organization (WHO)2023GuidanceAnglais
1.2. Promouvoir la demande pour la vaccination contre le paludism : Guide de planificationWorld Health Organization (WHO)2023GuidanceFrançais
1.3. Promover a demanda da vacinacao contra a malaria: Um guia de planeamentoWorld Health Organization (WHO)2023GuidancePortuguais
2.1. Risk Communications on Malaria Vaccination: A GuideWorld Health Organization (WHO)2023GuidanceAnglais
2.2. Communication sur les risques: La vaccination contre le paludisme: Un guideWorld Health Organization (WHO)2023GuidanceFrançais
2.3. Comunicacoes de riscos sobre a vacinacao contra a malaria: Um guiaWorld Health Organization (WHO)2023GuidancePortuguais

Resources for vaccine implementation

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1 RTS,S/AS01 (Mosquirix) 4-dose age-based administration: Essential Training Package for Malaria Vaccine IntroductionWorld Health Organization (WHO)2023TrainingAnglais, Français, Portuguais
RTS,S/AS01 (Mosquirix) Reconstitution training video (HD 1080p)GlaxoSmithKline (GSK) 2018TrainingAnglais
RTS,S/AS01 (Mosquirix) reconstitution training video (HD 720p)GlaxoSmithKline (GSK) 2018TrainingAnglais
RTS,S/AS01 (Mosquirix) Reconstitution training video (SD 360p)GlaxoSmithKline (GSK) 2018TrainingAnglais
RTS,S/AS01 (Mosquirix) Reconstitution training video (SD 540p)GlaxoSmithKline (GSK) 2018TrainingAnglais
RTS,S/AS01 (Mosquirix) vidéo de reconstitutionGlaxoSmithKline (GSK) 2024TrainingFrançais

Resources for monitoring and evaluation

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Appendix 4: Sample supportive supervision questions (Guide for introducing a malaria vaccine)World Health Organization (WHO)2023GuidanceAnglais

Coming soon!