Article de revue

“Why has this new vaccine come and for what reasons?” key antecedents and questions for acceptance of a future maternal GBS vaccine: Perspectives of pregnant women, lactating women, and community members in Kenya

Group B streptococcus (GBS) is a leading global cause of neonatal sepsis and meningitis, stillbirth, and puerperal sepsis. While intrapartum antibiotic prophylaxis (IAP) is a currently available GBS disease prevention strategy, IAP is programmatically complex to implement, precluding use in low- and middle-income countries. In Kenya, 2% of stillbirths are attributable to GBS infection. Two maternal GBS vaccines are in late-stage clinical development. However, licensure of a maternal GBS vaccine does not translate into reduction of disease. We conducted 28 in-depth interviews with pregnant people, lactating people, and community members across two counties in Kenya to better understand the attitudes and informational needs of primary vaccine beneficiaries. We identified two emerging themes from the data. The first focused on antecedents to maternal GBS vaccine acceptability. The most common antecedents focused on the vaccine’s ability to protect the baby and/or the mother, followed by community sensitization before the vaccine was available. The second key theme focused on questions that would need to be addressed before someone could accept a maternal GBS vaccine. Three key categories of questions were identified, including vaccine safety compared to vaccine benefits, who gets the vaccine, and how the vaccine works. Realizing the potential benefits of a future GBS maternal vaccine will require a multifactorial approach, including ensuring that communities are aware of GBS-related harms as well as the safety and effectiveness of a maternal GBS vaccine. Our study contributes to informing this multifactorial approach by elucidating the attitudes and concerns of key populations.

Langues

  • Anglais

Année de publication

2024

Journal

Human Vaccines & Immunotherapeutics

Type

Article de revue

Catégories

  • Initiatives mondiales

Références sur le sujet

MIRI-DEMAND

TitreAuteurAnnéeTypeLangue
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Maternal Immunization Readiness Initiative (MIRI) Kenya Results Dissemination Day 2 SlidesRupali J. Limaye, Prachi Singh, Berhaun Fesshaye, Eleonor Zavala, Clarice Lee, Ruth A. Karron2023PresentationAnglais
Maternal Immunization Readiness Initiative (MIRI) Kenya Results Dissemination Day 3 SlidesRupali J. Limaye, Prachi Singh, Berhaun Fesshaye, Eleonor Zavala, Clarice Lee, Ruth A. Karron2023PresentationAnglais
RSV awareness, risk perception, causes, and terms: Perspectives of pregnant and lactating women in Kenya to inform demand generation efforts for maternal RSV vaccinesRupali J. Limaye, Berhaun Fesshaye, Prachi Singh, Ruth A. Karron2023Journal articleAnglais
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Ajouté par: Berhaun Fesshaye

Ajouté le: 2024-02-21 15:12:35

Consultations: 390