Article de revue
Assessing the potency and immunogenicity of inactivated poliovirus vaccine after exposure to freezing temperatures
According to manufacturers, inactivated poliovirus vaccines (IPVs) are freeze sensitive and require storage between 2°C and 8°C, whereas oral poliovirus vaccine requires storage at -20 °C. Introducing IPV into ongoing immunization services might result in accidental exposure to freezing temperatures and potential loss of vaccine potency. To better understand the effect of freezing IPVs, samples of single-dose vaccine vials from Statens Serum Institut (VeroPol) and multi-dose vaccine vials from Sanofi Pasteur (IPOL) were exposed to freezing temperatures mimicking what a vaccine vial might encounter in the field. D-antigen content was measured to determine the in vitro potency by ELISA. Immunogenicity testing was conducted for a subset of exposed IPVs using the rat model. Freezing VeroPol had no detectable effect on in vitro potency (D-antigen content) in all exposures tested. Freezing of the IPOL vaccine for 7 days at -20 °C showed statistically significant decreases in D-antigen content by ELISA in poliovirus type 1 (p < 0.0001) and type 3 (p = 0.048). Reduction of poliovirus type 2 potency also approached significance (p = 0.062). The observed loss in D-antigen content did not affect immunogenicity in the rat model. Further work is required to determine the significance of the loss observed and the implications for vaccine handling policies and practices.
Auteurs
Langues
- Anglais
Année de publication
2018
Journal
Biologicals
Volume
53
Type
Article de revue
Catégories
- Vaccins et dispositifs d'administration
Maladies
- Polio
FREEZE-PREVENTION-POTENCY
Vous pouvez trouver plus d’informations sur "FREEZE-PREVENTION-POTENCY" dans les rubriques suivantes :
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Cold chain study: danger of freezing vaccines | P. Milhomme | Journal article | Anglais | |
| Hepatitis B vaccine | Arlene A. McLean, Raymond Shaw Jr. | Journal article | Anglais | |
| Hepatitis B vaccine in healthy hospital employees | R. Normand, R. Silberman, S. A. Klotz | Journal article | Anglais | |
| Comparison of hepatitis B vaccine coverage and effectiveness among urban and rural Mongolian 2-year-olds | Ann Marie Kimball, Arslan Rinchin, J. Khulan, James S. Edstam, Nyamkhuu Dulmaa, Pagbajabyn Nymadawa | Journal article | Anglais | |
| Performance and potency of tetanus toxoid: implications for eliminating neonatal tetanus | J. Bennett, S. Cochi, F. van Loon, J. B. Milstien, V. Dietz | 1996 | Journal article | Anglais |
| Storage at -3 degrees C for 24 h alters the immunogenicity of pertussis vaccines | Christina Ann Boros, D. M. Roberton, M. Hanlon, Michael Steven Gold | Journal article | Anglais | |
| Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles | Dvorah Diminsky, Marian Gorecki, Neomi Moav, Yechezkel Barenholz | Journal article | Anglais | |
| Effects of freezing on DPT and DPT-IPV vaccines, adsorbed | R. Dimayuga, D. Scheifele, A. Bell | 1995 | Journal article | Anglais, Français |
| Factors affecting the immunogenicity and potency of tetanus toxoid: implications for the elimination of neonatal and non-neonatal tetanus as public health problems | V. Dietz, A. Galazka, F. van Loon, S. Cochi | 1997 | Journal article | Anglais |
| Assessing the potency and immunogenicity of inactivated poliovirus vaccine after exposure to freezing temperatures | Jessica A. White, Jacqueline Fournier-Caruana, Diana Kouiavskaia, Konstantin Chumakov, William C. Weldon, Marcus Estrada, Dexiang Chen, Abhijeet Anand, Cynthia J. Snider, M. Steven Oberste, Edmond F. Maes, Howard E. Gary Jr., Eric Stevens | 2018 | Journal article | Anglais |
