Improving immunization coverage and equity - technical resources

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Resource Contribution of vaccination to improved survival and health: modelling 50 years of the Expanded Programme on Immunization
Purpose This article reviews the health impact of the Expanded Programme on Immunization (EPI) over its 50-year history. It assesses the global benefits of immunization efforts in reducing mortality and morbidity from vaccine-preventable diseases since the establishment of EPI in 1974.
Content This modeling study presents the global impact of vaccination in terms of numbers of deaths averted, years of life saved, and years of full health gained due to vaccination (i.e. disability-adjusted life-years averted). The analysis estimated vaccination’s contribution to decline in global infant mortality as well as increased survival probability. The article also covers major milestones and achievements that increased global access to vaccines and future directions for expanding immunization coverage.
Use This review can be used by health professionals, policymakers, and researchers to understand the long-term health benefits of global immunization efforts. It serves as evidence for continued investment in immunization programs and informs strategic decisions for future vaccination initiatives, especially in low- and middle-income countries.
Contraints/Limitations Any limitations inherent to underlying model outputs are also present in this analysis. The results presented are a conservative estimate because they
does not include deaths that will yet be averted by vaccines given in the last 50 years (e.g. longer term benefits of HepB and HPV), flow-on effects of vaccines on non-communicable disease are not captured, and quantification of vaccine impact is limited to 14 diseases only.
Example criteria this resource could address Assessing the cumulative impact of global vaccination efforts on public health.
If available, notes on the development process The article has been developed through a collaborative effort among global health experts, modelers, epidemiologists, and vaccine researchers.
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