These guidelines are meant to guide and assist Immunization Programme Officers and other stakeholders, Managers at National, State, District and Sub-district levels, Administrators, and Health Workers to plan and rollout the Human Papillomavirus (HPV) vaccination Campaign. The objective of these operational guidelines is to provide evidence-based technical information and ensure the operational feasibility of HPV vaccination Campaign. These guidelines are developed using following global resources: 1. HPV Vaccine Profiles (https://www.gavi.org/sites/default/files/document/2022/Gavi-HPV-vaccinesprofile-Jan_2022_0.pdf) 2. HPV VACCINE SCHEDULE OPTIMIZATION, Key considerations for decision-making, planning, and implementation, WHO 2023 (https://www.technet-21.org/en/hpv-vaccine-introduction/single-doseschedule) 3. Considerations for human papillomavirus (HPV) vaccine product choice, second edition https://iris. who.int/bitstream/handle/10665/379113/9789240100930-eng.pdf?sequence=1andisAllowed=y 4. WHO Position Paper 2022 (https://iris.who.int/server/api/core/bitstreams/182d51d2-6d08-4963- a643-43d4bc843189/content) 5. HPV Dashboard (https://www.who.int/teams/immunization-vaccines-and-biologicals/diseases/ human-papillomavirus-vaccines-(HPV)/hpv-clearing-house/hpv-dashboard)