Estimating the impact of vaccines in reducing antimicrobial resistance and antibiotic use: technical report

This report provides an in-depth evaluation of the potential role of vaccines in reducing antimicrobial resistance (AMR). It outlines the importance of vaccines as a crucial tool in preventing infections and curbing the spread of resistant strains, thus reducing reliance on antibiotics. Historically, the role of vaccines in reducing AMR has not been fully recognized, with the focus primarily on their use for preventing infectious diseases.

This report is unique in its comprehensive assessment of 44 vaccines targeting 24 pathogens, encompassing both licensed vaccines and those in development. It incorporates a robust methodology to estimate the potential impact of these vaccines on AMR-related health outcomes, antibiotic use, and economic costs. What sets this report apart is its detailed modelling of the burden averted by vaccines and the feasibility of development for each pathogen. The findings underscore the critical role vaccines must play in national and global AMR mitigation strategies.