Malaria vaccine introduction – technical resources

Eliane Furrer

In October 2023, WHO recommended the programmatic use of malaria vaccines for the prevention of P. falciparum malaria in children living in malaria endemic areas, prioritizing areas of moderate and high transmission.

This page provides a summary of the current global recommendations, evidence and programmatic considerations for malaria vaccine introduction into national immunization programmes – including implementation guidance, demand promotion and communications in support of malaria vaccine uptake, health worker generic training resources (to adapt for country use) and a series of technical references, publications and information resources.

Lessons learned from country-level pilot experiences (in Ghana, Kenya and Malawi) are also integrated into guidance to further inform planning and implementation. The content and guidance on this page are curated and maintained by the WHO Department of Immunization, Vaccines, and Biologicals.

The following resources aim to support immunization programme decision-makers and managers, immunization partners and stakeholders, and national malaria control programmes (NMCPs) in the following areas:

Resources for decision-making

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Global guidance 

TitleAuthorYearTypeLanguage
Malaria vaccine - WHO position paperWorld Health Organization (WHO)2024GuidanceEnglish, French
WHO Guidelines for malariaWorld Health Organization (WHO)2022GuidanceArabic, English, Spanish, French
WHO prequalification - Mosquirix (RTS,S/AS01)World Health Organization (WHO)2022GuidanceEnglish
WHO Prequalification - R21 MalariaWorld Health Organization (WHO)2023GuidanceEnglish

Evidence reports and publications

TitleAuthorYearTypeLanguage
Full evidence report on the R21/Matrix-M malaria vaccineWorld Health Organization (WHO)2023ReportEnglish
Full evidence report on the RTS,S/AS01 malaria vaccineWorld Health Organization (WHO)2021ReportEnglish
Malaria vaccine GRADE Evidence table2023ReportEnglish
Malaria Vaccine Evidence-to-Recommendations Framework: R21/Matrix-M2023ReportEnglish

Q&A and infographics on guidance and evidence 

TitleAuthorYearTypeLanguage
Malaria vaccine - questions and answersWorld Health Organization (WHO)GuidanceEnglish, French
Malaria vaccine: Questions and answers on supply, price, and market shapingUNICEFGuidanceEnglish, French

Resources for planning 

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Implementation guidance 

TitleAuthorYearTypeLanguage
1. Guide for introducing a malaria vaccine into national immunization programmes (draft)World Health Organization (WHO)2025GuidanceEnglish, French, Portuguese
2. Malaria vaccine introduction readiness assessment toolWorld Health Organization (WHO)2023GuidanceEnglish, French, Portuguese
3. Dose 4 start: information from WHO for countries implementing malaria vaccinesWorld Health Organization (WHO)2024GuidanceEnglish, French
WHO considerations where to introduce malaria vaccinesWorld Health Organization (WHO)2025GuidanceEnglish, French

Resources for demand promotion and communications 

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The tools listed below offer practical and adaptable guidance on how to: carry out planning and coordination, gather and use behavioural data to inform interventions, support health worker interactions, engage with communities, promote accurate information, and connect malaria vaccination activities to broader integrated approaches for strengthening vaccination programmes and malaria prevention and control. 

TitleAuthorYearTypeLanguage
1. Promoting Demand for Malaria Vaccination: A Planning GuideWorld Health Organization (WHO)2023GuidanceEnglish, French, Portuguese
2. Risk Communications on Malaria Vaccination: A GuideWorld Health Organization (WHO)2023GuidanceEnglish, French, Portuguese
0. Key messages on malaria vaccination for health workers and caregiversWorld Health Organization (WHO)2023GuidanceEnglish, French

Resources for vaccine implementation

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Training

TitleAuthorYearTypeLanguage
Essential Training Package for Malaria Vaccines (RTS,S and R21): age-based delivery approachWorld Health Organization (WHO)2023TrainingEnglish, Portuguese, French
RTS,S/AS01 (Mosquirix) reconstitution training video (HD 720p)GlaxoSmithKline (GSK) 2018TrainingEnglish
RTS,S/AS01 (Mosquirix) Reconstitution training video (SD 360p)GlaxoSmithKline (GSK) 2018TrainingEnglish
RTS,S/AS01 (Mosquirix) Reconstitution training video (HD 1080p)GlaxoSmithKline (GSK) 2018TrainingEnglish, French
RTS,S/AS01 (Mosquirix) Reconstitution training video (SD 540p)GlaxoSmithKline (GSK) 2018TrainingEnglish

Resources for monitoring and evaluation

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TitleAuthorYearTypeLanguage
0. Sample supportive supervision questions (Appendix: Guide for introducing a malaria vaccine)World Health Organization (WHO)2023GuidanceEnglish
1.0 Mini-mPIE introduction slidesetWorld Health Organization (WHO)2024PresentationEnglish, French
1.0 Malaria Vaccine Mini Post-Introduction Evaluation (Mini-mPIE) Guide (Draft)World Health Organization (WHO)2024GuidanceEnglish, French
1.2 Mini-mPIE Health Facility Questionnaire (Appendix 2)World Health Organization (WHO)2024ToolEnglish, French
1.3 Mini-mPIE caregiver questionnaire (Appendix 3)World Health Organization (WHO)2024ToolEnglish, French
1.4 Mini-mPIE note taking template (Appendix 4)World Health Organization (WHO)2024ToolEnglish, French
1.5 Mini-mPIE final report template (Appendix 5)World Health Organization (WHO)2024ToolEnglish, French
1.1 Mini-mPIE trigger question database (Appendix 1)World Health Organization (WHO)2024ToolEnglish, French
2.0 Malaria PIE Guide and AppendixWorld Health Organization (WHO)2025GuidanceEnglish, French
2.2.1 Malaria PIE Appendix 2.1 National QuestionnaireWorld Health Organization (WHO)2025ToolEnglish, French
2.2.2 Malaria PIE Appendix 2.2 Regional/District Questionnaire World Health Organization (WHO)2025ToolEnglish
2.2.3 Malaria PIE Appendix 2.3 Health Facility Questionnaire World Health Organization (WHO)2025ToolEnglish, French
2.2.4 Malaria PIE Appendix 2.4 Vaccine Storage ObservationWorld Health Organization (WHO)2025ToolEnglish, French
2.2.5 Malaria PIE Appendix 2.5 Vaccine Session ObservationWorld Health Organization (WHO)2025ToolEnglish, French
2.2.6 Malaria PIE Appendix 2.6 Caregiver QuestionnaireWorld Health Organization (WHO)2025ToolEnglish, French
2.4 Malaria PIE Appendix 4 Summary of QuestionnairesWorld Health Organization (WHO)2025ToolEnglish, French
2.5 Malaria PIE Appendix 5 Country Presentation TemplateWorld Health Organization (WHO)2025PresentationEnglish, French
2.6 Malaria PIE Appendix 6 Figures TemplateWorld Health Organization (WHO)2025ToolEnglish, French
2.8 Malaria PIE Appendix 8 Follow up Action PlanWorld Health Organization (WHO)2025ToolEnglish, French