Guidance

Guidance on selecting, commissioning and using freeze-preventative vaccine carriers

The cold chain is necessary to prevent damage to vaccines caused by heat exposure. However, improper use of cold chain equipment may cause damage to freeze-sensitive vaccines. Studies conducted in several countries with hot and cold climates show frequent occurrences of sub-zero temperatures in the cold chain. The most common cause of exposure to freezing temperature is the failure to correctly condition ice packs prior to transport. Some vaccines that are inadvertently frozen lose potency, increase wastage rates and increase the risk of adverse events following immunization (AEFI).

Vaccine carriers protect vaccine potency during immunization sessions and transport to outreach sites. This guidance document is intended to help inform which type of vaccine carrier to select based on local context, to maintain vaccine quality, especially at service delivery points.

 

Languages

  • Arabic
  • Chinese
  • English
  • French
  • Portuguese
  • Russian
  • Spanish

Publication year

2021

Type

Guidance

Categories

  • Supply chain & logistics

Organisations

  • World Health Organization (WHO)

Tags

  • Cold box / vaccine carrier
  • EQUIP

By EVM criterion

  • E6 Stock management
  • E7 Distribution of vaccines and dry goods
  • R2 Equipment management

Fundamental infrastructure and Management

TitleAuthorYearTypeLanguage
Decommissioning and safe disposal of cold chain equipmentUNICEF, World Health Organization (WHO)2018GuidanceEnglish
Cold chain equipment and dry store temperature mapping toolWorld Health Organization (WHO)2021ToolEnglish
How to temperature map cold chain equipment and storage areas, 2nd edWorld Health Organization (WHO)2022ToolEnglish
Cold Chain Temperature Data Job AidJSI, PATH, VillageReach, New Horizons2025GuidanceEnglish
Total Cost of Ownership Tool for Cold Chain EquipmentPATH2016ToolEnglish
Cold chain equipment inventory guidelines: Improving the quality and accuracy of national cold chain equipment inventory dataVillageReach, Gavi, the Vaccine Alliance, PATH2020GuidanceEnglish, French
Guidance on selecting, commissioning and using freeze-preventative vaccine carriersWorld Health Organization (WHO)2021GuidanceArabic, Chinese, English, French, Portuguese, Russian, Spanish
Using freeze-preventive cold boxes in rural Nepal: A study of equipment performance, acceptability, system fit, and costSandeep Kumar, Pat Lennon, Surendra Uranw2024Journal articleEnglish
Evaluating potential program cost savings with a single-dose HPV vaccination schedule: a modeling study.Rose Slavkosky, Mercy Mvundura, Frédéric Debellut, Teddy Naddumba2024Journal articleEnglish
Temperature monitoring study: a fully documented process to detect weaknesses in the supply chainWorld Health Organization (WHO), UNICEF2018GuidanceEnglish
Guidance on sustainable health-care waste management Michelle Seidel, Ranjit Dhiman, Terry Hart2023GuidanceEnglish
Guidance on the selection of green and safe healthcare waste treatment technologyRidwan Gustiana, Isabelle Cantin, Ranjit Dhiman, Sophie De Fries, Martin Bjerregaard, Lindsay Marie Denny2025GuidanceEnglish
NATIONAL HEALTH CARE WASTE MANAGEMENT STRATEGYRanjit Dhiman, Ute Pieper, Michelle Seidel2025GuidanceEnglish
Health-Care facility Solar Electrification for Climate-Resilient and Environmentally Sustainable Health-Care FacilitiesTerry Hart, Ranjit Dhiman, Michelle Seidel2023GuidanceEnglish

Added by: Dan Brigden

Added on: 2021-01-11 01:23:11

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