With the objective to correctly implement the standard of Effective Vaccine Management at central, regional district and up to immunization center and to enhance the quality of the cold chain management in order to provide services as well as to train the health workers this standard operating procedure was prepared. Context book and handbook distributed during training to all level staffs involving in vaccine management will help them complete work post training. This book is useful for those who wish to gain knowledge and information on effective vaccine management. I am hopeful that all the workers involved in vaccine management from central level vaccine store to immunization center will implement their respective work according to this handbook and contribute in providing quality immunization services. The basics of standard operating procedure by world health organization was translated in Nepali language for the development of training package to provide training to health worker.