Co-administration of monovalent, bivalent, and trivalent oral polio vaccines interferes with monovalent rotavirus vaccine immunogenicity in rural Bangladesh

Trivalent oral poliovirus vaccine (tOPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity. Interference with bivalent and monovalent OPV formulations, which will be increasingly used globally in coming years, has not been examined. The researchers conducted a post-hoc analysis to assess the interference of co-administration of different OPV formulations on RV1 immunogenicity.