Dosing regimen of the 23-valent pneumococcal vaccination: A systematic review

Currently, one lifetime booster of a 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended for those at highest risk of invasive pneumococcal disease (IPD) 3–5 years after initial vaccination. Due to a lack of evidence on multiple revaccinations, recommendations on repeat revaccination do not exist. The researchers aimed to determine the optimal dose and timing of PPV23 booster in high-risk groups.