Journal article
Effectiveness of a third dose of MMR vaccine for mumps outbreak control
BACKGROUND: The effect of a third dose of the measles–mumps–rubella (MMR) vaccine in stemming a mumps outbreak is unknown. During an outbreak among vaccinated students at the University of Iowa, health officials implemented a widespread MMR vaccine campaign. We evaluated the effectiveness of a third dose for outbreak control and assessed for waning immunity.
METHODS: Of 20,496 university students who were enrolled during the 2015–2016 academic year, mumps was diagnosed in 259 students. We used Fisher’s exact test to compare unadjusted attack rates according to dose status and years since receipt of the second MMR vaccine dose. We used multivariable time-dependent Cox regression models to evaluate vaccine effectiveness, according to dose status (three vs. two doses and two vs. no doses) after adjustment for the number of years since the second dose.
Authors
Languages
- English
Publication year
2017
Journal
N Engl J Med
Volume
377
Issue
10
Type
Journal article
Categories
- Service delivery
Diseases
- Mumps
Tags
- Outbreak
