Journal article
Immunization Coverage Surveys and Linked Biomarker Serosurveys in Three Regions in Ethiopia
OBJECTIVE:
Demographic and health surveys, immunization coverage surveys and administrative data often divergently estimate vaccination coverage, which hinders pinpointing districts where immunization services require strengthening. We assayed vaccination coverage in three regions in Ethiopia by coverage surveys and linked serosurveys.
METHODS:
Households with children aged 12-23 (N = 300) or 6-8 months (N = 100) in each of three districts (woredas) were randomly selected for immunization coverage surveys (inspection of vaccination cards and immunization clinic records and maternal recall) and linked serosurveys. IgG-ELISA serologic biomarkers included tetanus antitoxin ≥ 0.15 IU/ml in toddlers (receipt of tetanus toxoid) and Haemophilus influenzae type b (Hib) anti-capsular titers ≥ 1.0 mcg/ml in infants (timely receipt of Hib vaccine).
FINDINGS:
Coverage surveys enrolled 1,181 children across three woredas; 1,023 (87%) also enrolled in linked serosurveys. Administrative data over-estimated coverage compared to surveys, while maternal recall was unreliable. Serologic biomarkers documented a hierarchy among the districts. Biomarker measurement in infants provided insight on timeliness of vaccination not deducible from toddler results.
CONCLUSION:
Neither administrative projections, vaccination card or EPI register inspections, nor parental recall, substitute for objective serological biomarker measurement. Including infants in serosurveys informs on vaccination timeliness.
Authors
- Mark A Travassos
- Myron M Levine
-
Robert Steinglass
View profile | More articles - Marcela F. Pasetti
- Samba O Sow
- Jaya Goswami
- Inna Ruslanova
- Yukun Wu
- William C. Blackwelder
- Mardi Reymann
- Jenny Sequeira
-
Lisa Oot
View profile | More articles - Tassew Kassa
- Seydou S Diarra
- Nigisti Mulholland
- James D Campbell
- Zenaw Adam
- Berhane Beyene
- Amha Kebede
Languages
- English
Publication year
2016
Journal
PLoS One
Volume
2016 Mar 2;11(3):e0149970. doi: 10.1371/journal.pone.0149970. eCollection 2016.
Type
Journal article
Categories
- Data
Countries
- Ethiopia
Tags
- EQUIP
- Zero-dose
COV-METH-PUB
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