Journal article
Immunogenicity and safety of the human papillomavirus vaccine in patients with autoimmune diseases: A systematic review
Whereas safety and efficacy of HPV vaccines in healthy women have been shown in several randomised controlled clinical trials and in post marketing analyses, only few data exist in patients affected by autoimmune diseases. These issues are significant as autoimmune conditions are recognised as a risk factor for the persistence of HPV infection. Herein the researchers review and systematise the existing literature to assess immunogenicity and safety of HPV vaccination in patients with autoimmune diseases, including systemic lupus erythematosus and juvenile idiopathic arthritis. The results suggest that the HPV vaccines are efficacious and safe in most of the patients affected by autoimmune diseases. Yet, some points of concern remain to be tackled, including the effects of concomitant therapies, the risk of disease exacerbation and the cost-effectiveness of such immunisation programmes in these populations.
Languages
- English
Publication year
2015
Journal
Vaccine
Volume
33
Issue
30
Type
Journal article
Categories
- Service delivery
Diseases
- HPV
Tags
- New vaccine introduction
