Journal article

Overview of clinical trials and developments with the inactivated vaccine against Japanese encephalitis

The mosquito-borne Japanese encephalitis virus causes an estimated 50,000 cases in Asia, accounting for at least 10,000 deaths and 15,000 cases of neuropsychiatric sequelae. IXIARO® (Intercell AG, Vienna, Austria), an inactivated, Vero cell-derived vaccine against Japanese encephalitis was introduced in 2009. The vaccine is highly immunogenic, showing significantly higher geometric mean antibody titers compared with previous, mouse brain-derived vaccines. Postmarketing studies have confirmed the excellent safety profile. Studies on children aged 2 months to 18 years have been published. Based on these data, positive opinion from the EMA for vaccination of children has recently been given. Since a safe and effective vaccine against Japanese encephalitis is now available, outdated guidelines and recommendations have to be revised: travelers to rural areas of Asia should generally be recommended vaccination.

Authors

Languages

  • English

Publication year

2013

Journal

Expert Rev Vaccines.

Volume

Ahead of Print

Type

Journal article

Categories

  • Vaccines & delivery devices

Diseases

  • Japanese encephalitis

Countries

  • Japan

Vaccines

  • JE (inactivated)