Journal article
Short-term stress experienced at time of immunization induces a long-lasting increase in immunologic memory
It would be extremely beneficial if one could harness natural, endogenous, health-promoting defense mechanisms to fight disease and restore health. The psychophysiological stress response is the most underappreciated of nature\'s survival mechanisms. The researchers show that acute stress experienced before primary immunization induces a long-lasting increase in immunity. Compared with controls, mice restrained for 2.5 h before primary immunization with keyhole limpet hemocyanin (KLH) show a significantly enhanced immune response when reexposed to KLH 9 mo later. This immunoenhancement is mediated by an increase in numbers of memory and effector helper T cells in sentinel lymph nodes at the time of primary immunization.
Languages
- English
Publication year
2015
Journal
American Journal of Physiology
Volume
3
Type
Journal article
Categories
- Service delivery
