This is a simple, Excel-based tool for assessing and comparing financial costs of human papillomavirus (HPV) vaccine immunization programs with each HPV vaccine product available in the global market. It aims to help country-level policymakers specifically in middle-income countries compare products and estimate vaccination program costs for different HPV vaccines, exploring up to four different vaccine options at a time. The tool calculates cold chain volume and costs annually and for a total period of five years. Cost estimates are composed of vaccine cost (i.e., vaccine and supplies procurement and international shipping) and vaccination program costs (i.e., vaccine cost and cost of delivery). This new tool is more flexible than PATH's initial set of Vaccine Cost Calculators to better meet the needs of middle-income countries. For example, users can include a domestically produced vaccine option that is not available in the global market, as well as compare costs for up to three different scenarios of multi-vaccine use as some countries may plan to use more than one product at the same time. A six-minute video providing a brief tutorial on using the calculator is available in English, French, and Spanish - see links to the right.