Over the last decade, the technology environment in developing countries has changed significantly, offering new opportunities to strengthen and automate information systems throughout the health system. Health system supply chains in many countries are leveraging this changed environment, with digital solutions that support reporting at different levels of the supply chain. To complement the many excellent articles in Vaccine Journal's special issue on next generation immunization supply chains, JSI, VillageReach, VaxTrac and Drury Consulting have issued Critical Success Factors for Deploying Digital LMIS. Based on valuable lessons learned from early adopters of digital logistics management information systems, this paper provides ministries of health, development partners, and implementers with nine essential tactics for successfully deploying information technology to operate next generation medicine and vaccine supply chains.