This report presents a series of brief case studies supported by the existing literature on the deployment of digital solutions during the COVID-19 pandemic. It specifically describes how electronic Immunization Registries (eIR) and electronic Logistics Management Information Systems (eLMIS) have been newly developed and/or repurposed in Guinea, Honduras, India, Rwanda, and Tanzania. Importantly, the findings are influenced by the state of the implementation which, because of the delayed availability of COVID-19 vaccines in the LMICs, is still in its early phase.