Guidance

Effects of freezing on vaccine potency

This document provides a literature review of articles about the effects of freezing on vaccine potency of hepatitis B, tetanus toxoid, diphtheria, and pertussis vaccines. Also included is a review of stability data of these vaccines at temperatures below 0°C. This document is part of a series that describes the serious risk of freezing vaccines and World Health Organization-recommended freeze-prevention strategies targeted toward all levels of storage and transport of vaccines.

Authors

Languages

  • English

Publication year

2003

Publisher

PATH

Type

Guidance

Categories

  • Supply chain & logistics

Diseases

  • Diphtheria

Topic references

FREEZE-PREVENTION-BACKGROUND

TitleAuthorYearTypeLanguage
Above Zero: Strategies to Prevent Vaccine FreezingPATH2013TrainingEnglish
Effects of freezing on vaccine potencyPATH2003GuidanceEnglish
Freezing temperatures in the vaccine cold chain: A systematic literature reviewCarib Nelson, Dipika M. Matthias, Joanie Robertson, Michelle M. Garrison, Sophie NewlandJournal articleEnglish
Is freezing in the vaccine cold chain an ongoing issue? A literature reviewAdama Sawadogo, Anupa M. George, Benjamin Schreiber, Celina M. HansonJournal articleEnglish