Immunization programs around the world have new and familiar challenges to preventing life-altering diseases. After focusing on COVID-19 vaccine programs for the past few years, countries now look to strengthen routine immunization and program recovery to prevent further backslides and outbreaks of vaccine-preventable diseases. Whether for COVID-19 or routine childhood immunization, vaccines bring us closer to giving everyone a chance to pursue full, healthy lives. JSI is committed to helping countries build equitable and strong health systems that support people’s well-being. This edition includes highlights of our work.