Guidance

Frequently Asked Questions (FAQ) on use of fractional dosing with intradermal administration of mpox MVA-BN vaccine in the context of vaccine supply-constrained outbreak response

This document outlines key considerations for the use of fractional dosing with intradermal administration of the MVA-BN mpox vaccine in response to ongoing mpox outbreaks. In light of the limited availability of vaccine and current WHO recommendations, national authorities may, as a temporary outbreak response measure, consider administering MVA-BN vaccine via intradermal injection at a reduced dose to protect individuals at risk of exposure.

Languages

  • English

Publication year

2025

Type

Guidance

Categories

  • Vaccines & delivery devices

Diseases

  • Mpox

Organisations

  • World Health Organization (WHO)

Tags

  • Emergencies
  • Outbreak
  • Vaccine management
  • Vaccine supply

WHO Regions

  • African Region

Mpox-Policy

You can find more information about "Mpox-Policy" in the following Hot Topics:

TitleAuthorYearTypeLanguage
Smallpox and mpox (orthopoxviruses): WHO position paperWorld Health Organization (WHO)2024GuidanceEnglish, French
Summary of WHO SAGE recommendations for mpox vaccines, including considerations for off-label useWorld Health Organization (WHO)2025PresentationEnglish
Off-label vaccine use: explanatory note for countriesWorld Health Organization (WHO)2024GuidanceEnglish
MVA-BN (‎Modified Vaccinia Ankara – Bavarian Nordic)‎ smallpox and mpox vaccine: Interim guidanceWorld Health Organization (WHO)2024GuidanceEnglish, French
ETF statement on the use of Imvanex for the prevention of mpox in children below 12 years of ageEuropean Medicines Agency2024GuidanceEnglish
Regulatory & Policy Considerations for Mpox Vaccines in African CountriesWorld Health Organization (WHO), European Medicines Agency, Bavarian Nordic2025PresentationEnglish
LC16m8 (live-attenuated freeze-dried vaccinia) smallpox and mpox vaccine - Interim GuidanceWorld Health Organization (WHO)2025GuidanceEnglish, French
Frequently Asked Questions (FAQ) on use of fractional dosing with intradermal administration of mpox MVA-BN vaccine in the context of vaccine supply-constrained outbreak responseWorld Health Organization (WHO)2025GuidanceEnglish

Added by: Miluka Gunaratna

Added on: 2025-06-25 10:57:02

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